Today's show is brought to you by the Essential RX segment with Dr. Lametra Scott. The VitaminSC3 Podcast is powered by the Sickle Cell Community Consortium.
Dr. Ted Kieffer is an American Board of Pathology certified Clinical Pathologist and Transfusion Medicine specialist with specialized training in Clinical Microbiology. He received his medical school, residency, and fellowship training at Indiana University and Indiana University Hospitals pathology program. Dr.Kieffer has worked in medical reimbursement as a senior Healthcare consultant, an associate professor and medical director with West Virginia University and hospital systems, and Cell and Gene Therapy Medical director with a local Tennessee non-profit blood center. He is engaged in several national and international societies and currently sits on the BSR/PDA apheresis collection for cell and gene therapy products standards committee, the intenational society for cell and gene therapy's laboratory professionals committee, and was recently offered the appointment to the TN state Board of Medical Laborator as a Pathologist representative.
When Where There Be a Universal Cure to Sickle Cell Disease?
Today's episode is about gene therapy, stem cells, and bone marrow transplants. Today's show will provide a basic framework of sickle cell and gene therapy and how they differ from a bone marrow transplant.
Today's Topic: Is a Universal Cure to Sickle Cell Disease on the Horizon?
- Dr. Kieffer explains what happens during a bone marrow transplant and how it is different than gene therapy on a pathologic level: Timestamp 06:38
- Explain the term Myeloablative. Timestamp 10:27
Myeloablative HSCT is the more stringent type of treatment. HSCT destroys the body's (autoreactive) lymphocytes and the bone marrow (source
- Where are we in curative therapies, and how are they different from the bone marrow transplant process? Timestamp 13:43
- Gene editing vs. LentiGlobin Gene Therapy. Timestamp 21:12
- Curative Therapies are usually only offered to sickle cell patients in dire conditions. Why isn't it provided to more patients sooner? Timestamp 27:00
Tweet able quote: "Healthcare has to be a dialog, it has to be ownership by the treating team." - Ted Kieffer
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